Assistant Project Scientist Research Development of new methodologies for modeling biological systems. Working on different projects aiming to understand by means of mathematical modeling diverse biological phenomena with particular focus on heat stroke. Education B.S., Chemical Engineering, University of Santiago de Compostela, Spain, 2001 Ph.D., Chemical Engineering, IIM-CSIC, University of Vigo, Spain, 2007 SensSB Tool […]
Assistant Project Manager Research 1. Systems modeling and analysis of circadian rhythm networks, reverse engineering of synchrony as an algorithmic strategy for wireless communication network control. 2. Fault detection, control and estimation for networked control systems (control systems whose control loops are closed via a serial communication channel) subject to random network-induced delay, packet dropout, […]
Ph.D. Awarded, May 2015 Department of Chemical Engineering Mitsubishi Chemical Fellowship Recipient Research Circadian rhythms – found in nearly all living systems – are the result of complex biochemical pathways which allow organisms to synchronize with their environment. My research seeks to reverse engineer these systems to better understand how life maintains robust, accurate timekeeping […]
Former Graduate Student, Department of Electrical and Computer Engineering Fulbright Scholarship Recipient Research Control theory and its application to networks. I am currently focusing on Bio-inspired strategies to achieve robust synchronization of networks of autonomous agents communicating using wireless channels. Our algorithms aim to achieve fast synchronization while maintaining robustness with respect to network topology, […]
Y. Q. Wang, F. J. Doyle III. “Optimal phase response functions for fast pulse-coupled synchronization in wireless sensor networks,” IEEE Transactions on Signal Processing. vol. 60, no. 10, 2012, pp. 5583–5588, October 2012. [DOI]
Y. Q. Wang, F. Nunez, F. J. Doyle III. “Energy-efficient pulse-coupled synchronization strategy design for wireless sensor networks through reduced idle listening,” IEEE Transactions on Signal Processing, vol. 60, no. 10, 2012, pp. 5293–5306, October 2012. [DOI]
K. Sriram, M. Rodriguez-Fernandez, F.J. Doyle III, “A Detailed Modular Analysis of Heat-Shock Protein Dynamics under Acute and Chronic Stress and its Implication in Anxiety Disorders”, PLoS ONE, vol. 7, no. 8, e42958, August 2012. [DOI]
A press release for a recent paper published in collaboration with researchers from UCSD. Read More Full Citation: T. Hirota, J. W. Lee, P. C. St. John, M. Sawa, K. Iwaisako, T. Noguchi, P. Y. Pongsawakul, T. Sonntag, D. K. Welsh, D. a Brenner, F. J. Doyle, P. G. Schultz, and S. a Kay, “Identification […]
T. Hirota, J.W. Lee, P.C St. John, M. Sawa, K. Iwaisako, T. Noguchi, P.Y. Pongsawakul, T. Sontag, D.K. Welsh, D.A. Brenner, F.J. Doyle III, P.G. Schultz, S.A. Kay, “Identification of small molecule activators of cryptochrome,” Science, vol. 337, no. 6098, pp. 1094-1097, July 2012. [DOI]
K. Sriram, M. Rodriguez-Fernandez, F.J. Doyle III, “Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans”, PLoS Computational Biology, vol. 8, no. 2, e1002379, February 2012. [DOI]
Developing control systems for medical applications poses significant challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops. The dynamics vary both between different individuals, and within the same individual over time. Measurement and estimation of both inter- and intra-patient […]
The success of the human genome project has ushered in a new era that emphasizes a systemic or integrated approach to ascertain the cellular behavior arising from complex cellular networks. Scientists are now embarking on a quest to elucidate the organization and control of cellular networks that underlie the phenotypic behavior of a cell; these […]
Sansum Diabetes Research Institute
Our experimental collaborators, a research center devoted to the prevention, treatment and cure of diabetes http://www.sansum.org/
Developing control systems for medical applications poses significant challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops. The dynamics vary both between different individuals, and within the same individual over time. Measurement and estimation of both inter- and intra-patient […]
The success of the human genome project has ushered in a new era that emphasizes a systemic or integrated approach to ascertain the cellular behavior arising from complex cellular networks. Scientists are now embarking on a quest to elucidate the organization and control of cellular networks that underlie the phenotypic behavior of a cell; these […]
