PhD Candidate, Applied Mathematics John A. Paulson School of Engineering and Applied Sciences Harvard University Research My research focuses on the use of different mathematical techniques, including both continuous differential equation based models and more discrete machine learning techniques, to explore biological systems, including those involved in the development of circadian rhythms and post traumatic stress […]
J.H. Abel, K. Meeker, D. Granados-Fuentes, P.C. St. John, T.J. Wang, B.B. Bales, F.J. Doyle III, E.D. Herzog, L.R. Petzold. “Functional network inference of the suprachiasmatic nucleus.” Proceedings of the National Academy of Sciences of the United States of America, 113(16), 2016. doi:10.1073/pnas.1521178113
J.H. Abel, L.A. Widmer, P.C. St. John, J. Stelling, and F.J. Doyle III, ” A Coupled Stochastic Model Explains Differences in Cry Knockout Behavior.” IEEE Life Sciences Letters, Jun 2015. doi:10.1109/LLS.2015.2439498
Post Doctoral Fellow Systems Biology and Biomedical Control Research Systems Biological studies for linking PTSD, Circadian rhythms and metabolic diseases in Humans. Modeling of Physiological process and analysis of disease mechanisms for target identification. Multi-scale data analysis and Machine learning for Bio-markers identification in disease systems. Feedback Control analysis of biological networks to identify regulatory […]
G.S. Thakur, B.J. Daigle Jr, K.R. Dean, Y. Zhang, M. Rodriguez-Fernandez, R. Hammamieh, R. Yang, M. Jett, J. Palma, L.R. Petzold, F.J. Doyle III, “Systems biology approach to understanding post-traumatic stress disorder,” Molecular bioSystems, Jan 2015. [DOI]
P.C. St John, S.R. Taylor, J.H. Abel, F.J. Doyle III, “Amplitude metrics for cellular circadian bioluminescence reporters,” Biophysical Journal, vol. 107, no. 11, pp. 2712-22,Dec 2014. [DOI]
PhD, Systems Biology 2018 Harvard University T32 Trainee in Sleep, Circadian, and Respiratory Neurobiology Harvard Medical School/Brigham and Women’s Hospital Research The circadian oscillator is a biological control system designed to regulate gene expression in a 24-hour periodic environment. The gene regulatory network comprising the circadian oscillator may be modeled through systems of coupled chemical […]
See a press release covering our recent publication, Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock: UC Santa Barbara researchers’ new insight into mammalian circadian rhythms could lead to therapies for certain metabolic disorders like obesity and diabetes – See more at: http://www.news.ucsb.edu/2014/013919/resetting-metabolic-clock#sthash.kbLzwK6r.dpuf Related News Stories http://www.redorbit.com/news/health/1113058004/circadian-rhythms-key-to-treating-metabolic-disorders-012914/ http://blogs.voanews.com/science-world/2014/01/29/new-body-clock-info-could-help-treat-diabetes-obesity/ http://www.news-medical.net/news/20140130/New-insight-into-mammalian-circadian-rhythms-could-lead-to-therapies-for-metabolic-disorders.aspx http://www.biosciencetechnology.com/news/2014/01/resetting-metabolic-clock#.UuqMRCR1FI0 […]
P.C. St John, T. Hirota, S.A. Kay, F.J. Doyle III, “Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock,” Proceedings of the National Academy of Sciences of the United States of America, Jan 2014. [DOI]
PhD Candidate, Systems Biology Harvard University Research My research focuses on identifying and characterizing distinct biological subtypes of Posttraumatic Stress Disorder (PTSD) which may be related to disease stratification or progression. These subtypes will give us insight into identifying robust blood biomarkers for diagnosing PTSD. My current work aims to investigate methods to integrate multiple […]
Developing control systems for medical applications poses significant challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops. The dynamics vary both between different individuals, and within the same individual over time. Measurement and estimation of both inter- and intra-patient […]
The success of the human genome project has ushered in a new era that emphasizes a systemic or integrated approach to ascertain the cellular behavior arising from complex cellular networks. Scientists are now embarking on a quest to elucidate the organization and control of cellular networks that underlie the phenotypic behavior of a cell; these […]
Sansum Diabetes Research Institute
Our experimental collaborators, a research center devoted to the prevention, treatment and cure of diabetes http://www.sansum.org/
Developing control systems for medical applications poses significant challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops. The dynamics vary both between different individuals, and within the same individual over time. Measurement and estimation of both inter- and intra-patient […]
The success of the human genome project has ushered in a new era that emphasizes a systemic or integrated approach to ascertain the cellular behavior arising from complex cellular networks. Scientists are now embarking on a quest to elucidate the organization and control of cellular networks that underlie the phenotypic behavior of a cell; these […]
