Tag: sysbio

Lindsey Brown
March 26, 2017 Read More →

Lindsey Brown

PhD Candidate, Applied Mathematics John A. Paulson School of Engineering and Applied Sciences Harvard University Research My research focuses on the use of different mathematical techniques, including both continuous differential equation based models and more discrete machine learning techniques, to explore biological systems, including those involved in the development of circadian rhythms and post traumatic stress […]

April 4, 2016 Read More →

Functional network inference of the suprachiasmatic nucleus

J.H. Abel, K. Meeker, D. Granados-Fuentes, P.C. St. John, T.J. Wang, B.B. Bales, F.J. Doyle III, E.D. Herzog, L.R. Petzold. “Functional network inference of the suprachiasmatic nucleus.” Proceedings of the National Academy of Sciences of the United States of America, 113(16), 2016. doi:10.1073/pnas.1521178113

September 3, 2015 Read More →

A Coupled Stochastic Model Explains Differences in Cry Knockout Behavior

J.H. Abel, L.A. Widmer, P.C. St. John, J. Stelling, and F.J. Doyle III, ” A Coupled Stochastic Model Explains Differences in Cry Knockout Behavior.” IEEE Life Sciences Letters, Jun 2015. doi:10.1109/LLS.2015.2439498

Pramod Rajaram S
September 2, 2015 Read More →

Pramod Rajaram S

Post Doctoral Fellow Systems Biology and Biomedical Control Research Systems Biological studies for linking PTSD, Circadian rhythms and metabolic diseases in Humans. Modeling of Physiological process and analysis of disease mechanisms for target identification. Multi-scale data analysis and Machine learning for Bio-markers identification in disease systems. Feedback Control analysis of biological networks to identify regulatory […]

Posted in: Recent Alumni
January 28, 2015 Read More →

Systems biology approach to understanding post-traumatic stress disorder

G.S. Thakur, B.J. Daigle Jr, K.R. Dean, Y. Zhang, M. Rodriguez-Fernandez, R. Hammamieh, R. Yang, M. Jett, J. Palma, L.R. Petzold, F.J. Doyle III, “Systems biology approach to understanding post-traumatic stress disorder,” Molecular bioSystems, Jan 2015. [DOI]

December 2, 2014 Read More →

Amplitude metrics for cellular circadian bioluminescence reporters

P.C. St John, S.R. Taylor, J.H. Abel, F.J. Doyle III, “Amplitude metrics for cellular circadian bioluminescence reporters,” Biophysical Journal, vol. 107, no. 11, pp. 2712-22,Dec 2014. [DOI]

John Abel
February 25, 2014 Read More →

John Abel

PhD, Systems Biology 2018 Harvard University T32 Trainee in Sleep, Circadian, and Respiratory Neurobiology Harvard Medical School/Brigham and Women’s Hospital Research The circadian oscillator is a biological control system designed to regulate gene expression in a 24-hour periodic environment. The gene regulatory network comprising the circadian oscillator may be modeled through systems of coupled chemical […]

Posted in: Recent Alumni
Resetting the Metabolic Clock
January 28, 2014 Read More →

Resetting the Metabolic Clock

See a press release covering our recent publication, Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock: UC Santa Barbara researchers’ new insight into mammalian circadian rhythms could lead to therapies for certain metabolic disorders like obesity and diabetes – See more at: http://www.news.ucsb.edu/2014/013919/resetting-metabolic-clock#sthash.kbLzwK6r.dpuf Related News Stories http://www.redorbit.com/news/health/1113058004/circadian-rhythms-key-to-treating-metabolic-disorders-012914/ http://blogs.voanews.com/science-world/2014/01/29/new-body-clock-info-could-help-treat-diabetes-obesity/ http://www.news-medical.net/news/20140130/New-insight-into-mammalian-circadian-rhythms-could-lead-to-therapies-for-metabolic-disorders.aspx http://www.biosciencetechnology.com/news/2014/01/resetting-metabolic-clock#.UuqMRCR1FI0 […]

Posted in: News
January 21, 2014 Read More →

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock

P.C. St John, T. Hirota, S.A. Kay, F.J. Doyle III, “Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock,” Proceedings of the National Academy of Sciences of the United States of America, Jan 2014. [DOI]

Kelsey Dean
November 14, 2013 Read More →

Kelsey Dean

PhD Candidate, Systems Biology Harvard University Research My research focuses on identifying and characterizing distinct biological subtypes of Posttraumatic Stress Disorder (PTSD) which may be related to disease stratification or progression. These subtypes will give us insight into identifying robust blood biomarkers for diagnosing PTSD. My current work aims to investigate methods to integrate multiple […]

Posted in: Recent Alumni